Tolerability and Safety of 30, 45, and 60 mg of Sublingual Lobeline. - 1

Tolerability, Safety, and Pharmacokinetics of Repeated Sublingual Doses of Lobeline

The purpose of this study is to assess safety and pharmacokinetics of sublingual lobeline in healthy normal volunteers.

Inclusion Criteria:

• Must be able to provide written informed consent
• Must have a body mass index between 18 and 30
• Have no medical contraindications as determined by medical history, physical exam, ECG, hematology and blood chemistry profile, and urinalysis
• Must have a negative drug test at screening and admission
• If female of child bearing potential, must agree to use birth control

Exclusion Criteria:

• Please contact the site for more information