One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery

One-lung ventilation; organ protection; volatile anesthetics

One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:

1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse?

2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.

   • Trial with immunomodulatory product / biological

Inclusion criteria:

• Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation

Exclusion criteria:

• Immunosuppressive therapy
• Ongoing inflammatory processes