The purpose of this study is to identify a safe and tolerable dose of the drug KU-0059436 that can be given in combination with gemcitabine chemotherapy for the treatment of pancreatic cancer.

Inclusion Criteria:

• Histologically or cytologically confirmed adenocarcinoma of pancreas
• Locally advanced or metastatic unresectable disease

Exclusion Criteria:

• No prior anti cancer chemotherapy, radiotherapy (except palliative >4 weeks prior to entry, endocrine or immunotherapy or use of other investigational agents;