Will oral vitamin improve strength, bone quality, pain and quality of life. This is a double blind, randomized placebo controlled study using 10,000 IU of cholecalciferol vs placebo.

The proposed study is be a randomized, double-blind, placebo-controlled trial of supplementation with oral vitamin D3.

Each subject will take a once-weekly capsule containing vitamin D3 or a an identical-appearing placebo for a treatment period of 15 weeks.

Subjects will be assessed for Bone pain and tenderness, Neuromuscular function, physical performance score, and Quality of life assessment.

A subset of subjects will have bone biopsies performed before and after intervention.

Inclusion Criteria:

• On dialysis
• Likely to be able to complete the study
• At least minimally ambulatory, with or without a walking aid (i.e., cane or walker)
• Able to complete the various questionnaires interactively with the research nurse
• Venous access that can be accomplished without unusual difficulty.