A study to compare the conversion to Prograf® (tacrolimus) to the continuation of cyclosporine in patients at risk for chronic renal allograft failure

A two arm study (1 Active, 1 Active control) to compare the incidence, progression and severity of chronic renal allograft failure in at-risk patients who are converted from cyclosporine-based to tacrolimus-based immunosuppression to patients who remain on cyclosporine-based therapy

Inclusion Criteria:

• Patient has been on cyclosporine-based immunosuppression regimen since the transplant
• Patient has at least one pre-defined risk factor for chronic allograft failure

Exclusion Criteria:

• Patient is dialysis dependent
• Patient is recipient of a solid organ transplant other than the kidney