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| ID | Type | Description | Link |
|---|---|---|---|
| NMU2007092 |
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| Name | Class |
|---|---|
| HRSA/Maternal and Child Health Bureau | FED |
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Intravenous patient-controlled analgesia (PCA) is a popular technique for postoperative pain management. Although several drugs are recognized as effective therapeutic options, optimal selection of drugs in hysterectomy patients underwent different anesthesia treatments remains unknown explicitly. The investigators hypothesized that butorphanol and tramadol can produce different analgesic effects with intravenous PCA after abdominal hysterectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Butorphanol basal infusion adjunct to morphine PCA |
|
| 2 | Experimental | Saline infusion adjunct to morphine PCA |
|
| 3 | Experimental | Premedication of Tramadol |
|
| 4 | Experimental | Preemptive saline for morphine PCA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Saline | Drug | Saline infusion adjunct to morphine PCA pump |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| VAS pain scoring; | 5 months |
| Measure | Description | Time Frame |
|---|---|---|
| VAS sedation scoring; VAS happiness scoring; Adverse effects; Patient's overall conditions. | 5 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| XiaoFeng Shen, MD | Nanjing Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanjing Maternal and Child Care Hospital | Nanjing | Jiangsu | 210004 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19122548 | Result | Wang F, Shen X, Liu Y, Xu S, Guo X. Continuous infusion of butorphanol combined with intravenous morphine patient-controlled analgesia after total abdominal hysterectomy: a randomized, double-blind controlled trial. Eur J Anaesthesiol. 2009 Jan;26(1):28-34. doi: 10.1097/EJA.0b013e32831a6aa2. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D002077 | Butorphanol |
| D014147 | Tramadol |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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| Butorphanol tartrate | Drug | Butorphanol was delivered at a continuous infusion manner adjunct to morphine PCA pump |
|
|
| Tramadol Hydrochloride | Drug | 100mg tramadol was used preemptively to morphine PCA pump |
|
|
| Saline | Drug | Preemptive saline as a control group to tramadol one |
|
|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009422 | Nervous System Diseases |
| D017670 |
| Sodium Compounds |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D004123 | Dimethylamines |
| D008744 | Methylamines |
| D000588 | Amines |
| D008055 | Lipids |