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Standard treatment of patients with acute ST-segment elevation myocardial infarction consist of acute re-opening of the occluded coronary artery (primary PCI). Despite successful treatment of the epicardial vessel reperfusion is sometimes inadequate leading to large final infarct sizes. This phenomenon is known as the reperfusion injury. Several animal studies have indicated that graded re-opening of the artery may limit tissue damage. Generally this is referred to as mechanical postconditioning.
The study investigates the effect on final infarct size evaluated by magnetic resonance scan of postconditioning of ST-segment elevation myocardial infarctions. Mechanical postconditioning is performed by means of several balloon inflations in the injured vessel following its acute re-opening.
Please see above
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mek postcon | Experimental | Re-opening of the infarcted coronary artery by several balloon inflations separated by reperfusion of the vessel. |
|
| Standard treatment | Active Comparator | Standard treatment (primary PCI) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard primary PCI | Procedure | Acute re-opening of the occluded coronary artery |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Final infarct size evaluated by MR | 3 month |
| Measure | Description | Time Frame |
|---|---|---|
| MACE (death, re-infarction, TLR) | 1, 15 month | |
| Stent thrombosis | 15 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thomas Engstrom, D.Sci., PhD | Cheif Consultant | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiac Catherization Lab., Heart Center, Rigshospitalet, University of Copenhagen | Copenhagen | 2100 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21146662 | Derived | Lonborg J, Holmvang L, Kelbaek H, Vejlstrup N, Jorgensen E, Helqvist S, Saunamaki K, Clemmensen P, Treiman M, Jensen JS, Engstrom T. ST-Segment resolution and clinical outcome with ischemic postconditioning and comparison to magnetic resonance. Am Heart J. 2010 Dec;160(6):1085-91. doi: 10.1016/j.ahj.2010.09.026. | |
| 20118154 | Derived |
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| Mechanical postconditioning |
| Procedure |
Mechanical postconditioning with 4 cycles 30/30 sek balloon inflations |
|
| Lonborg J, Kelbaek H, Vejlstrup N, Jorgensen E, Helqvist S, Saunamaki K, Clemmensen P, Holmvang L, Treiman M, Jensen JS, Engstrom T. Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Circ Cardiovasc Interv. 2010 Feb 1;3(1):34-41. doi: 10.1161/CIRCINTERVENTIONS.109.905521. Epub 2010 Jan 26. |