Treatment of Hypersensitivity Syndrome (DRESS) With Tegeline® (Human Immunoglobulin)

Treatment of DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) With Tegeline®

Efficacy and tolerance of Tegeline® treatment in hypersensitivity syndrome. Immunological study of the T cell index phenotype and functionality in hypersensitivity syndrome.

Inclusion Criteria:

• Age >= 18
• Cutaneous and/or mucous eruption
• Polyadenopathy
• Body temperature > 38°C
• Hematology disorders : Hypereosinophily > 1.5 G/l, lymphocytosis > 5G/l, atypical blood lymphocytes
• Consent obtained from patient

Exclusion Criteria:

• Age < 18
• No consent obtained from patient
• IgV allergy
• Dress with very sérious visceral attack and vital diagnostic (sharp cardiac insufficiency, sharp respiratory insufficiency, hepatic insufficiency, sharp renal insufficiency)
• Oral therapy or immunosuppressive therapy (Methotrexate, cyclosporine, cyclophosphamide, etc.)
• IgA deficiency,
• MCI >=35
• Sharp renal insufficiency before Dress with creatinaemia < 60 ml/min (Cockroft)