Vascular and Lipid Effects of Omega-3 Fatty Acids in People With Moderately Elevated Triglycerides

Omacor: Measures of Endothelial Function and triGlyceride Alteration

The purpose of this study is to evaluate the cardiovascular and lipid effects of two doses of an omega-3 fatty acid concentrate in a group of people who normally are not treated for high lipids.

Inclusion Criteria:

• triglycerides 150-500 mg/dL
• age 21-65 years
• generally healthy
• body mass index (BMI) 20-39 kg/m2

Exclusion Criteria:

• smoking
• premenopausal (if female)
• use of hormone replacement or oral contraceptives
• use of lipid lowering or blood pressure medication
• hypertension (blood pressure > 150/95 mm Hg)
• peripheral vascular disease
• heart disease, diabetes, or stroke
• inflammatory disease (e.g. rheumatoid arthritis or Crohn's)
• elevated liver enzymes
• high intake of omega-3 containing foods
• allergy to adhesive or latex
• use of aspirin, anticoagulants, or SSRI