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An open, phase 1 to assess the PK of rising doses of ZD6474 when administered daily in Chinese patients with advanced solid malignant tumors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 100 mg Vandetanib eod | Experimental | 100 mg Vandetanib every other day dosing |
|
| 100 mg Vandetanib od | Experimental | 100 mg Vandetanib once daily dosing |
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| 300 mg Vandetanib od | Experimental | 300 mg Vandetanib once daily dosing |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vandetanib | Drug | 100 mg every other day, 100mg once daily |
|
| Measure | Description | Time Frame |
|---|---|---|
| Area under the curve (AUC) (0-24) (ng.h/mL) after single dose | Blood sample is collected at 1, 2, 4, 6, 8, 10 & 24 hour after first single dose on day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Sciences & Operations | Sanofi | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Guangzhou | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21600385 | Background | Zhang L, Li S, Zhang Y, Zhan J, Zou BY, Smith R, Martin PD, Jiang Y, Liao H, Guan Z. Pharmacokinetics and tolerability of vandetanib in Chinese patients with solid, malignant tumors: an open-label, phase I, rising multiple-dose study. Clin Ther. 2011 Mar;33(3):315-27. doi: 10.1016/j.clinthera.2011.04.005. |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| C452423 | vandetanib |
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| Vandetanib 300 mg | Drug | 300mg once daily |
|
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