Tolerability, Safety and Efficacy of SAD448 in Subjects With Ocular Hypertension

A Multicenter, Randomized, Placebo-Controlled, Double-Masked, 4-Arm Parallel Group Study to Assess the Tolerability, Safety and Efficacy of Two Doses of SAD448 in Subjects With Ocular Hypertension

This study will evaluate the tolerability and safety of SAD448 and explore the compound's effect on intraocular pressure in subjects with ocular hypertension.

Key inclusion criteria:

• Males and females, 18 - 65 years of age, with ocular hypertension
• Females must be post-menopausal or surgically sterile

Key exclusion criteria:

• Diagnosis of glaucoma in either eye
• A history of or current eye conditions or medical problems that would prohibit the use of an investigational drug