A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease | NCT00501059 | Trialant

A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease | NCT00501059 | Trialant

Official Title: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel Group Study to Assess the Efficacy (Reduction of Cardiovascular Disease Events) and Safety of 100 mg Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease
Brief Summary: The use of acetylsalicylic acid in the primary prevention of cardiovascular events has been extensively studied but to a lesser extent in patients with moderate levels of cardiovascular risk. The current study is designed to prove the efficacy and tolerability of 100 mg enteric-coated Aspirin versus placebo in the prevention of cardiovascular disease (CVD) events, which include fatal and nonfatal myocardial infarction, fatal and nonfatal stroke and CV death, in a population with no history of known CVD who are at moderate risk of major CHD events (approximately 10-20% 10 year CHD risk). This corresponds to a patient population mean 10-year CVD risk of approximately 30%. Subjects are treated in a standard care setting and may receive treatment for the underlying risk factors as defined by the treating physician. Outcome events will be adjudicated by an Endpoint Adjudication Committee and the study will be monitored by an independent Data Safety Monitoring Board.
Detailed Description: Summary of substantial Protocol amendments

Amendment #2 from 09-APR-2008:

Systolic blood pressure (SBP) limit of 170 mmHg has been added to the exclusion criteria

Exclusion of patients currently taking anticoagulant medication

A longer interval between the daily dose of study drug and ibuprofen

Revised wording in moderate risk definitions for coronary heart disease (CHD) and cerebrovascular disease (CVD): "To evaluate the clinical effects of a 100 mg/day enteric-coated acetylsalicylic acid versus placebo in the reduction of CVD events in patients at moderate risk of major CHD events (approximately 10 to 20% 10-year CHD risk; approximately 20 to 30% 10-year risk of CVD). This corresponds to a patient population mean 10-year CVD risk of approximately 30%."

Amendment #3 from 02-JAN-2009

• Increase in the number of allowed risk factors for males, age is no longer a risk factor

Amendment #4 from 02-OCT-2013

The primary endpoint is changed to include confirmed UA and TIA.

The estimated event rate is changed to 1.5% per year due to new information.

Effect size (risk reduction) changed from 14.9% to 17 to 18%.

Achieving 60,000 person-years instead of 1488 primary endpoint events

Additional treatment and follow-up for a maximum of another 12 months.

Change to reduced adverse event and concomitant therapy reporting

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Males aged 55 years and above with 2 to 4 risk factors. Male Risk Factors:

Elevated cholesterol (Tchol>200 mg/dL or LDL>130 mg/dL; as measured at screening) irrespective of current treatment

Current smoking: defined as any cigarette smoking in the past 12 months

Low HDL cholesterol (HDL<40 mg/dL; as measured at screening)

Elevated blood pressure (SBP>140 mmHg; as measured at screening)

Currently on any medication to treat high blood pressure

Positive family history of early CHD (a first-degree relative [father, mother, brother, sister, son, daughter] suffered a heart attack [myocardial infarction] before the age of 60 years)

Females aged 60 and above with 3 or more risk factors. Female Risk Factors:

Elevated cholesterol (Tchol>240 mg/dL or LDL>160 mg/dL; as measured at screening) irrespective of current treatment

Current smoking: defined as any cigarette smoking in the past 12 months

Low HDL cholesterol (HDL<40 mg/dL; as measured at screening)

Elevated blood pressure (SBP>140 mmHg; as measured at screening)

Currently on any medication to treat high blood pressure

Positive family history of early CHD (a first-degree relative [father, mother, brother, sister, son, daughter] suffered a heart attack [myocardial infarction] before the age of 60 years)

An understanding and willingness to comply with trial procedures and has given written informed consent to participate in the trial

Exclusion Criteria:

History of a documented vascular event, such as MI, stroke, coronary artery angioplasty or stenting, coronary artery bypass graft, relevant arrhythmias, or congestive heart failure or vascular intervention

Patients who are at higher than moderate risk on the basis of their diabetes status, other factors known to the investigator, or the currently used national risk score

Known contraindications to the study drug, e.g. hypersensitivity to acetylsalicylic acid

Recent (in the past year) history of gastrointestinal or genitourinary bleeding or other bleeding disorders

Active diagnosed and documented reflux esophagitis

Patients presenting with any medical condition, or psychiatric or substance abuse disorder, that, in the opinion of the investigator, is likely to affect the patient's ability to complete the study or precludes the patient's participation in the study

Lactating women or women of childbearing potential

Severe liver disease or damage based on the clinical judgment of the investigator

Severe renal disease or damage based on the clinical judgement of the investigator

A definite indication for acetylsalicylic acid therapy, other antiplatelet drug, or anticoagulant in the opinion of the physician

A history of asthma induced by administration of salicylates or substances with a similar action, notably NSAIDS

Chronic, frequent (> 5 days/month) use of NSAIDs (including aspirin, or aspirin containing products), COX-2 inhibitors or metamizole

Current participation in any other trials involving investigational products within 30 days prior to the Screening Visit

Current use of an anticoagulant medication

Sitting systolic blood pressure greater than 170 mmHg

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Birmingham, Alabama 39294, United States

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Graysville, Alabama 35073, United States

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Pell City, Alabama 35125, United States

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Phoenix, Arizona 85051, United States

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Scottsdale, Arizona 85260, United States

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Tucson, Arizona 85712, United States

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Hot Springs, Arkansas 71913-4457, United States

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Fremont, California 94536-3702, United States

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Huntington Park, California 90255, United States

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Los Angeles, California 90025, United States

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Rancho Cucamonga, California 91730, United States

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Rolling Hills Estates, California 90274, United States

Helping Hands Clinical Trials

Santa Ana, California 92704, United States

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Newark, Delaware 19702, United States

Medical Research Trust

Boynton Beach, Florida 33426, United States

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Gainesville, Florida 32601, United States

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Hialeah, Florida 33016, United States

Medical Research Centers of South Florida, Inc.

Hollywood, Florida 33021, United States

Office of Dr.Larry Levinson, DO

Hollywood, Florida 33021, United States

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Kissimmee, Florida 34741, United States

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Largo, Florida 33770, United States

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Marianna, Florida 32446-2120, United States

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Tallahassee Memorial Family

Quincy, Florida 32351, United States

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Tampa, Florida 33614, United States

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Atlanta, Georgia 30318, United States

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Chicago, Illinois 60628, United States

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Chicago, Illinois 60631-1958, United States

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Evansville, Indiana 47713, United States

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Cadillac, Michigan 49601, United States

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Interlochen, Michigan 49643-9264, United States

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Port Gibson, Mississippi 39150, United States

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Florissant, Missouri 63031, United States

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Broken Bow, Nebraska 68822, United States

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Omaha, Nebraska 68114, United States

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Omaha, Nebraska 68116-2004, United States

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Belvidere, New Jersey 07823, United States

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Cherry Hill, New Jersey 08084, United States

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Clifton, New Jersey 07013, United States

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Hainesport, New Jersey 08036, United States

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Jersey City, New Jersey 07306, United States

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Lawrenceville, New Jersey 08648, United States

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Linden, New Jersey 07036, United States

PharmaTrials, Inc.

Perth Amboy, New Jersey 08861, United States

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Stratford, New Jersey 08084, United States

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Burlington, North Carolina 27215, United States

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Columbus, North Carolina 28722, United States

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Greensboro, North Carolina 27401, United States

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Raleigh, North Carolina 27609, United States

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Carlisle, Ohio 45005-3320, United States

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Marion, Ohio 43302, United States

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Montgomery, Ohio 45242, United States

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Perrysburg, Ohio 43551, United States

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Doylestown, Pennsylvania 18901, United States

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Duncansville, Pennsylvania 16635, United States

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Sellersville, Pennsylvania 18960, United States

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Taylors, South Carolina 29687, United States

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Daingerfield, Texas 75638, United States

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McKinney, Texas 75069, United States

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Rockwall, Texas 75032, United States

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San Antonio, Texas 78205-1116, United States

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San Marcos, Texas 78666, United States

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Stephenville, Texas 76401, United States

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Sugar Land, Texas 77478, United States

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Honaker, Virginia 24260, United States

Merit Medical Group, Inc.

Richlands, Virginia 24641-2067, United States

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Benningen am Neckar, Baden-Wurttemberg 71726, Germany

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Deggingen, Baden-Wurttemberg 73326, Germany

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Dossenheim, Baden-Wurttemberg 69221, Germany

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Ettlingen, Baden-Wurttemberg 78275, Germany

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Graben-Neudorf, Baden-Wurttemberg 76676, Germany

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Heilbronn, Baden-Wurttemberg 74080, Germany

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Hockenheim, Baden-Wurttemberg 68766, Germany

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Ludwigsburg, Baden-Wurttemberg 71640, Germany

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Schwetzingen, Baden-Wurttemberg 68723, Germany

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Stockach, Baden-Wurttemberg 78333, Germany

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Trossingen, Baden-Wurttemberg 78647, Germany

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Weinheim, Baden-Wurttemberg 69469, Germany

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Arzberg, Bavaria 95659, Germany

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Bergrheinfeld, Bavaria 97493, Germany

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Dinkelsbühl, Bavaria 91550, Germany

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Gars, Bavaria 83536, Germany

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Hohenau, Bavaria 94545, Germany

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Künzing, Bavaria 94550, Germany

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München, Bavaria 80336, Germany

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Sand Am Main, Bavaria 97522, Germany

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Schrobenhausen, Bavaria 86529, Germany

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Spalt, Bavaria 91174, Germany

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Straßkirchen, Bavaria 94342, Germany

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Sulzbach-Rosenberg, Bavaria 92237, Germany

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Ursensollen, Bavaria 92289, Germany

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Cottbus, Brandenburg 03046, Germany

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Potsdam, Brandenburg 14778, Germany

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Hanau, Hesse 63450, Germany

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Kelkheim, Hesse 65779, Germany

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Rotenburg an der Fulda, Hesse 36199, Germany

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Wetter, Hesse 35083, Germany

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Aurich, Lower Saxony 26603, Germany

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Braunschweig, Lower Saxony 38100, Germany

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Loxstedt, Lower Saxony 27612, Germany

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Papenburg, Lower Saxony 26871, Germany

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Stuhr, Lower Saxony 28816, Germany

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Aachen, North Rhine-Westphalia 52074, Germany

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Bochum, North Rhine-Westphalia 44797, Germany

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Cologne, North Rhine-Westphalia 51069, Germany

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Duisburg, North Rhine-Westphalia 47199, Germany

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Essen, North Rhine-Westphalia 45130, Germany

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Essen, North Rhine-Westphalia 45136, Germany

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Essen, North Rhine-Westphalia 45276, Germany

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Essen, North Rhine-Westphalia 45355, Germany

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Essen, North Rhine-Westphalia 45359, Germany

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Freudenberg, North Rhine-Westphalia 57258, Germany

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Greven, North Rhine-Westphalia 48268, Germany

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Hamm, North Rhine-Westphalia 59069, Germany

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Hünxe, North Rhine-Westphalia 46569, Germany

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Kamp-Lintfort, North Rhine-Westphalia 47475, Germany

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Krefeld, North Rhine-Westphalia 47798, Germany

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Langenfeld, North Rhine-Westphalia 40764, Germany

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Lienen, North Rhine-Westphalia 49536, Germany

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Löhne, North Rhine-Westphalia 32584, Germany

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Marl, North Rhine-Westphalia 45770, Germany

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Münster, North Rhine-Westphalia 48167, Germany

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Netphen, North Rhine-Westphalia 57250, Germany

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Porta Westfalica, North Rhine-Westphalia 32457, Germany

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Remscheid, North Rhine-Westphalia 42897, Germany

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Siegen, North Rhine-Westphalia 57072, Germany

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Viersen, North Rhine-Westphalia 41751, Germany

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Welver, North Rhine-Westphalia 59514, Germany

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Kallstadt, Rhineland-Palatinate 67169, Germany

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Ludwigshafen am Rhein, Rhineland-Palatinate 67063, Germany

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Mainz, Rhineland-Palatinate 55116, Germany

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Mainz, Rhineland-Palatinate 55127, Germany

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Nassau, Rhineland-Palatinate 56377, Germany

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Rhaunen, Rhineland-Palatinate 55624, Germany

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Speyer, Rhineland-Palatinate 67346, Germany

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Beucha, Saxony 04824, Germany

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Borna, Saxony 04552, Germany

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Delitzsch, Saxony 04509, Germany

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Dresden, Saxony 01069, Germany

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Dresden, Saxony 01127, Germany

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Dresden, Saxony 01277, Germany

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Leipzig, Saxony 04103, Germany

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Leipzig, Saxony 04249, Germany

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Markkleeberg, Saxony 04416, Germany

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Meissen, Saxony 01662, Germany

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Oberwiesenthal, Saxony 09484, Germany

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Riesa, Saxony 01587, Germany

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Wermsdorf, Saxony 04779, Germany

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Bitterfeld-Wolfen, Saxony-Anhalt 06749, Germany

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Halle, Saxony-Anhalt 06124, Germany

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Magdeburg, Saxony-Anhalt 39104, Germany

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Bad Bramstedt, Schleswig-Holstein 24576, Germany

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Reinfeld, Schleswig-Holstein 23858, Germany

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Apolda, Thuringia 99510, Germany

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Blankenhain, Thuringia 99444, Germany

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Daaden, 57567, Germany

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Hamburg, 22041, Germany

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Hamburg, 22299, Germany

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Hamburg, 22335, Germany

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Rehburg-Loccum, 31547, Germany

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Riede, 27339, Germany

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Bishopstown, Cork, Ireland

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Cork, Ireland

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Dublin, 2, Ireland

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Chieti, Abruzzo 66100, Italy

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Foggia, Apulia 71100, Italy

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Amandola, Ascoli Piceno 63021, Italy

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Naples, Campania 80131, Italy

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Reggio Emilia, Emilia-Romagna 42019, Italy

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Chiavari, Genova 16043, Italy

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Rome, Lazio 00157, Italy

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Rome, Lazio 00161, Italy

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Como, Lombardy 22066, Italy

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Varese, Lombardy 21100, Italy

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Legnano, Milano 20025, Italy

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Novara, Piedmont 28100, Italy

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Turin, Piedmont 10023, Italy

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Catania, Sicily 95124, Italy

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Chieri, Torino 10023, Italy

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Moncalieri, Torino 10024, Italy

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Grosseto, Tuscany 58100, Italy

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Asti, 14100, Italy

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Bergamo, 24128, Italy

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Reggio Emilia, 42123, Italy

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Bialystok, 15-183, Poland

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Bydgoszcz, 85-863, Poland

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Bydgoszcz, Poland

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Chrzanów, Poland

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Czechowice-Dziedzice, Poland

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Elblag, 82-300, Poland

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Gdansk, 80-286, Poland

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Gdansk, 80-461, Poland

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Gdansk, 80-822, Poland

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Gdynia, 81-317, Poland

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Gliwice, 44-109, Poland

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Grodzisk Mazowiecki, 05-825, Poland

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Katowice, 40-226, Poland

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Katowice, 40-752, Poland

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Krakow, 30-424, Poland

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Krakow, 31-011, Poland

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Krakow, 31-156, Poland

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Krakow, 31-567, Poland

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Krakow, 31-637, Poland

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Krakow, Poland

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Kutno, 99-300, Poland

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Linia, 84-223, Poland

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Lodz, Poland

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Lublin, 20-044, Poland

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Lublin, 20-258, Poland

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Lublin, Poland

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Malbork, 82-200, Poland

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Małaszewicze, Poland

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Nakło nad Notecią, 98-100, Poland

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Olkusz, Poland

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Ostrów Wielkopolski, 63-400, Poland

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Poznan, 60-539, Poland

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Przeworsk, 37-200, Poland

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Radom, 26-600, Poland

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Skierniewice, 96-100, Poland

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Skierniewice, Poland

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Sobótka, Poland

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Sopot, 81-746, Poland

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Szczyrk, 43-370, Poland

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Warsaw, 01-192, Poland

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Warsaw, 02-507, Poland

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Warsaw, 02-796, Poland

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Wąbrzeźno, Poland

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Wejherowo, Poland

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Wola, Poland

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Wroclaw, 50-127, Poland

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Wroclaw, 51-112, Poland

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Włocławek, Poland

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Zabrze, Poland

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Guaynabo, 00968, Puerto Rico

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Manati, 00674, Puerto Rico

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Orocovis, 00720, Puerto Rico

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San Juan, 00918, Puerto Rico

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Trujillo Alto, 00976, Puerto Rico

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Sobrado Dos Monxes, A Coruña 15813, Spain

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La Roda, Albacete 06230, Spain

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Benidorm, Alicante 03503, Spain

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Elche, Alicante, Spain

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Petrel, Alicante 03610, Spain

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Xixona, Alicante 03100, Spain

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Vic (Barcelona), Catalonia 08500, Spain

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Begonte, Lugo 27373, Spain

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Viveiro, Lugo 27850, Spain

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Espinardo, Murcia 30100, Spain

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Ourense, Ourense 32003, Spain

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Oviedo, Principality of Asturias 33009, Spain

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Oviedo, Principality of Asturias 33013, Spain

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Posada de Llanes, Principality of Asturias 33594, Spain

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Gümar, Santa Cruz De Tenerife 38591, Spain

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La Victoria, Santa Cruz De Tenerife 38380, Spain

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Alcover, Tarragona 43460, Spain

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Albacete, 2260, Spain

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Alicante, 03007, Spain

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Badajoz, 06140, Spain

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Barcelona, 08017, Spain

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Barcelona, 08023, Spain

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Barcelona, 08025, Spain

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Huelva, 21003, Spain

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León, 24001, Spain

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León, Spain

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Lugo, 27770, Spain

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Madrid, 28003, Spain

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Madrid, 28030, Spain

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Madrid, 28032, Spain

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Murcia, 300005, Spain

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Murcia, 30007, Spain

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Murcia, 30008, Spain

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Salamanca, 27-31, Spain

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Santander, 39009, Spain

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Valladolid, 47007, Spain

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Ballymena, Antrim BT42 4JP, United Kingdom

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Ballymena, Antrim BT43 6JD, United Kingdom

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Crumlin, Antrim BT29 4LP, United Kingdom

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Newtonabbey, Antrim BT37 9QU, United Kingdom

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Craigavon, Armagh BT67 0LQ, United Kingdom

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Bath, Avon BA2 3HT, United Kingdom

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Bath, Avon BA2 4BY, United Kingdom

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Radstock, Avon BA3 2UH, United Kingdom

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Irvine, Ayrshire KA12 0AY, United Kingdom

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Luton, Bedfordshire LU2 9SB, United Kingdom

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Slough, Berkshire SL1 1TT, United Kingdom

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Ely, Cambridgeshire CB7 4HF, United Kingdom

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Ely, Cambridgeshire CB7 5SQ, United Kingdom

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Peterborough, Cambridgeshire PE2 5GP, United Kingdom

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Peterborough, Cambridgeshire PE7 3JL, United Kingdom

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Sandbach, Cheshire CW11 1EQ, United Kingdom

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Boscastle, Cornwall PL35 0BG, United Kingdom

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Fowey, Cornwall PL23 1DT, United Kingdom

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Penzance, Cornwall TR18 4EL, United Kingdom

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Penzance, Cornwall TR18 4JH, United Kingdom

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Penzance, Cornwall TR19 7HX, United Kingdom

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Saltash, Cornwall PL12 6DL, United Kingdom

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St Austell, Cornwall PL26 7RL, United Kingdom

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Chesterfield, Derbyshire S40 4AA, United Kingdom

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Dronfield, Derbyshire S18 8QY, United Kingdom

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Plymouth, Devon PL6 7TH, United Kingdom

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Carryduff, Down BT8 8HR, United Kingdom

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Annan, Dumfries And Galloway DG12 6BG, United Kingdom

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Bishop Auckland, Durham DL14 6AB, United Kingdom

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Darlington, Durham DL2 1AA, United Kingdom

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Darlington, Durham DL3 7JR, United Kingdom

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Darlington, Durham DL3 8SQ, United Kingdom

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Leigh-on-Sea, Essex SS9 2SQ, United Kingdom

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Tiptree, Essex CO5 0HB, United Kingdom

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High Valleyfield, Fife KY12 8SJ, United Kingdom

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Glasgow, Glasgow City G20 0XA, United Kingdom

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Bangor, Gwynedd BT19 1PP, United Kingdom

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Hitchin, Hertfordshire SG4 9TH, United Kingdom

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Letchworth Garden City, Hertfordshire SG6 4TS, United Kingdom

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Letchworth Garden City, Hertfordshire SG6 4UB, United Kingdom

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Canterbury, Kent CT1 3HX, United Kingdom

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Chestfield, Kent CT5 3QU, United Kingdom

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Whitstable, Kent CT5 3SE, United Kingdom

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Carstairs, Lanarkshire ML11 8QD, United Kingdom

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Coatbridge, Lanarkshire ML5 3AP, United Kingdom

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Forth, Lanarkshire ML1 8AJ, United Kingdom

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Blackpool, Lancashire FY3 7EN, United Kingdom

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Blackpool, Lancashire FY4 3AD, United Kingdom

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Bolton, Lancashire BL3 6TL, United Kingdom

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Bolton, Lancashire BL5 3UB, United Kingdom

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Hinckley, Leicestershire LE10 2SE, United Kingdom

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Wells-next-the-Sea, Norfolk NR23 1JP, United Kingdom

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Wymondham, Norfolk NR18 0RF, United Kingdom

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Antrim, North Ireland BT36 4PP, United Kingdom

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Antrim, North Ireland BT37 9QN, United Kingdom

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Antrim, North Ireland BT41 3AE, United Kingdom

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Tyrone, North Ireland BT80 8BG, United Kingdom

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Wellingborough, Northamptonshire NN8 4RW, United Kingdom

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Chipping Norton, Oxfordshire OX75FA, United Kingdom

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Eccles, Sheffield S35 9XQ, United Kingdom

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Bath, Somerset BA1 2SR, United Kingdom

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Barry, SOuth Glamorgan CF63 4HP, United Kingdom

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Doncaster, South Yorkshire DN1 2ET, United Kingdom

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Sheffield, South Yorkshire S7 2DW, United Kingdom

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Chapelhall, Stratchclyde ML6 8SR, United Kingdom

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Glasgow, Stratchclyde G45 9AW, United Kingdom

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Hamilton, Stratchclyde ML3 ODR, United Kingdom

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Johnstone, Stratchclyde PA5 8EY, United Kingdom

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Motherwell, Stratchclyde ML1 3JX, United Kingdom

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Bury Saint Edmonds, Suffolk IP30 9QU, United Kingdom

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Bury St Edmunds, Suffolk IP31 2HD, United Kingdom

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Bury St Edmunds, Suffolk IP32 7EW, United Kingdom

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Hadleigh, Suffolk IP7 5DN, United Kingdom

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Stowmarket, Suffolk IP14 1NL, United Kingdom

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Addlestone, Surrey KT15 2BH, United Kingdom

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East Horsley, Surrey KT24 6QT, United Kingdom

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Worcester Park, Surrey KT4 7BX, United Kingdom

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Newcastle upon Tyne, Tyne and Wear NE15 6TQ, United Kingdom

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Coventry, Warwickshire CV6 4DD, United Kingdom

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Coventry, Warwickshire CV7 8LA, United Kingdom

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Rugby, Warwickshire CV21 3SP, United Kingdom

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Coventry, West Midlands CV9 1EU, United Kingdom

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Brighton, West Sussex BN2 1ES, United Kingdom

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Crawley, West Sussex RH10 1LL, United Kingdom

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Crawley, West Sussex RH10 7DX, United Kingdom

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Leeds, West Yorkshire LS10 3NB, United Kingdom

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Leeds, West Yorkshire LS118BS, United Kingdom

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Leeds, West Yorkshire LS15 9JH, United Kingdom

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Leeds, West Yorkshire LS25 1AN, United Kingdom

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Leeds, West Yorkshire LS25 1HB, United Kingdom

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Leeds, West Yorkshire LS25 7AB, United Kingdom

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Leeds, West Yorkshire LS26 8SZ, United Kingdom

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Leeds, West Yorkshire LS9 9EF, United Kingdom

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Bradford-on-Avon, Wiltshire BA15 1DQ, United Kingdom

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Chippenham, Wiltshire SN14 6GT, United Kingdom

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Chippenham, Wiltshire SN15 2SB, United Kingdom

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Corsham, Wiltshire SN3 9DL, United Kingdom

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Trowbridge, Wiltshire BA14 9AR, United Kingdom

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Westbury, Wiltshire BA13 3FQ, United Kingdom

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Aberdeen, AB25 2ZD, United Kingdom

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Airedire, ML66DB, United Kingdom

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Antrim, BT38 9TG, United Kingdom

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Bath, BA11 2FH, United Kingdom

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Bath, BA2 4JT, United Kingdom

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Belfast, BT1 2JR, United Kingdom

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Belfast, BT12 5EY, United Kingdom

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Belfast, BT12 5LT, United Kingdom

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Belfast, BT13 3BW, United Kingdom

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Belfast, BT15 2GE, United Kingdom

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Belfast, BT5 7BP, United Kingdom

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Belfast, BT8 6GR, United Kingdom

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Belfast, United Kingdom

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Bellshill, ML4 1PS, United Kingdom

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Blantyre, G72 0BS, United Kingdom

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Cardiff, CF5 4AD, United Kingdom

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Coatrbridge, ML5 3BJ, United Kingdom

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Crossgar, BT30 9JU, United Kingdom

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Doncaster, DN1 2EU, United Kingdom

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Dundee, DD19SY, United Kingdom

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Glasgow, G21 1TR, United Kingdom

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Glasgow, G5 0BQ, United Kingdom

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Glasgow, G52 3QN, United Kingdom

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Glasgow, G67 1BJ, United Kingdom

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Hamilton, ML3 7EN, United Kingdom

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Hamilton, ML3 8AA, United Kingdom

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Inverness, IV2 4AG, United Kingdom

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Ipswich, IP4 2PU, United Kingdom

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Lockerbie, D11 2BJ, United Kingdom

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London, SW12 8EU, United Kingdom

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Manchester, M13 9WL, United Kingdom

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New Stevenson, ML1 4LT, United Kingdom

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Paisley, United Kingdom

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Peterborough, PE8 6PL, United Kingdom

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Thornhill, DG3 5AA, United Kingdom

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Watford, WD25 7NL, United Kingdom

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Wishaw, ML2 7BQ, United Kingdom

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Witley Bay, NE26 1NA, United Kingdom