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| ID | Type | Description | Link |
|---|---|---|---|
| K23DA018203 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The primary purpose of this investigation is to determine the predictive value of task persistence as measured by a mirror tracing task. A secondary purpose is to evaluate differences in task persistence in smokers with or without schizophrenia. It is hypothesized that task persistence in smokers in both diagnostic categories (schizophrenia and no schizophrenia) will predict tobacco dependence treatment outcome at one and six months. It is also hypothesized that smokers with schizophrenia will show lower levels of task persistence after controlling for other motor skills than smokers without schizophrenia.
Please see brief summary above.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-psychiatric smokers | Smokers not meeting criteria for Schizophrenia or Schizoaffective Disorder | ||
| Smokers with Schizophrenia | Smokers meeting criteria for schizophrenia or schizoaffective disorder |
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| Measure | Description | Time Frame |
|---|---|---|
| Mirror-tracing Persistence (in Seconds) | Number of seconds participants continued working on a mirror tracing task before giving up. | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Persistence as a Prospective Predictor of Smoking Cessation | Analysis of Generalized Estimating Equations (GEE) parameter estimates based on empirical standard error estimates, using an exchangeable working correlation structure, with smoking abstinence as outcome variable, and task persistence, time, diagnosis, ability, Fagerstrom Test for Nicotine Dependence (FTND) score, and the interaction between disorder and persistence as explanatory variables. |
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Inclusion Criteria:
Exclusion Criteria:
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Individuals from mental health centers in Central New Jersey or non-psychiatric controls from the community
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| Name | Affiliation | Role |
|---|---|---|
| Marc L. Steinberg, PH.D | Rutgers, The State University of New Jersey | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UMDNJ Tobacco Dependence Clinic | New Brunswick | New Jersey | 08901 | United States |
Reasons for exclusion included the following: Failed diagnostic screen, passed quit date/already using smoking cessation medications, changed mind about participating, smoked fewer than 10 cigarettes per day, did not have a goal to quit smoking, transportation issues, lost contact before baseline appointment, and low mini Mental Status Exam score.
A total of 203 smokers were recruited from New Jersey state funded tobacco dependence treatment clinics, called QuitCenters, through clinician referrals or responses to recruitment flyers.
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| ID | Title | Description |
|---|---|---|
| FG000 | Non-psychiatric Smokers | Smokers without a diagnosis of schizophrenia or schizoaffective disorder |
| FG001 | Smokers With Schizophrenia / Schizoaffective Disorder | Smokers meeting criteria for schizophrenia or schizoaffective disorder |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
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| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Diagnosis | Non-psychiatric group vs. Schizophrenia / Schizoaffective disorder |
| Units | Counts |
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| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Mirror-tracing Persistence (in Seconds) | Number of seconds participants continued working on a mirror tracing task before giving up. | All meeting inclusion criteria | Posted | Mean | Standard Deviation | seconds | baseline |
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No adverse events were reported by participants to investigators during this study.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Diagnosis | Non-psychiatric group vs. Schizophrenia / Schizoaffective disorder |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Marc L. Steinberg, Ph.D. | Rutgers, The State University of New Jersey | 732-235-4341 | marc.steinberg@rutgers.edu |
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| ID | Term |
|---|---|
| D014029 | Tobacco Use Disorder |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| 6 months |
| Participants |
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| Age, Continuous | Mean | Standard Deviation | years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Participants |
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| Secondary | Persistence as a Prospective Predictor of Smoking Cessation | Analysis of Generalized Estimating Equations (GEE) parameter estimates based on empirical standard error estimates, using an exchangeable working correlation structure, with smoking abstinence as outcome variable, and task persistence, time, diagnosis, ability, Fagerstrom Test for Nicotine Dependence (FTND) score, and the interaction between disorder and persistence as explanatory variables. | Posted | Number | 95% Confidence Interval | Odds ratio | 6 months |
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