Physical and Mental Assessment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Inpatient Functional and Cognitive Assessment in Older Adults With Acute Myelogenous Leukemia

RATIONALE: Learning about physical ability and mental function over time in older patients with acute myeloid leukemia may help doctors learn about the long-term effects of treatment and plan the best treatment.

PURPOSE: This clinical trial is assessing physical and mental status in older patients with newly diagnosed acute myeloid leukemia.

OBJECTIVES:

Primary

• Test the feasibility of pre-treatment, bedside assessment of functional and cognitive status in older adults with newly diagnosed acute myeloid leukemia (AML).

Secondary

• Obtain preliminary data regarding the predictive value of pre-treatment, bedside assessment of functional and cognitive status on overall survival, length of hospitalization and early death.

OUTLINE: This is a prospective study.

At baseline, patients complete questionnaires including the Vulnerable Elders Survey (functional status), the Mini-Mental Status Exam (cognition), and the Center for Epidemiologic Studies-Depression. Patients also undergo physical function testing via the Short Physical Performance Battery and hand grip strength. Further information parameters are obtained by periodic medical chart reviews.

Patients are followed every 3 months for up to 2 years.

DISEASE CHARACTERISTICS:

• Pathologically confirmed newly diagnosed acute myeloid leukemia
• Planned induction chemotherapy
• Inpatient status

PATIENT CHARACTERISTICS:

• No requirement for intensive care unit support

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• No prior therapy for acute myeloid leukemia