To evaluate the use of topical application of Nifedipine cream for the treatment of Provoked localized Vulvodynia (vestibulitis, vestibulodynia).

30 women aged 18-45 diagnosed with Provoked localized Vulvodynia will be included. 10 women will use topical Nifedipine cream 0.2% 4 times a day for 6 weeks (except for menstrual period). 10 other women will use topical Nifedipine cream 0.4% 4 times a day for 6 weeks (except for menstrual period).

10 women will be a control group and will use a placebo cream. The study will be randomized and double blind. Participants will be examined before starting the treatment, at the end of the treatment and 3 months after completion the treatment. A special detailed questionnaire has been prepared in three languages and will be used to compare dyspareunia and associate variables between the groups.

The Q-tip tests will be performed and findings will be drawn in each examination. Differences between the groups will be examined, and uni- and multi-variate analysis will be performed.

Inclusion Criteria:

1. Women diagnosed with vestibulitis according to Friedrich's criteria:

   • Severe pain with vestibular touch or attempted vaginal entry.
   • A positive Q-tip test: pain produced by touching the vestibule with a cotton tipped applicator.
   • Physical findings limited to varying degree of vestibular erythema.

2. Non-pregnant women aged 18-45.

3. Women use effective contraception and are not interested in becoming pregnant during the study period.

4. No known Nifedipine allergy.

5. No medical diseases.

Exclusion Criteria:

1. Women who have undergone vestibulectomy.
2. Active vaginal or pelvic infection.
3. A medical disease uch as Diabetes, immune suppression.