Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens

Determine the Effects of COL-101 Administered Once Daily With Metronidazole Topical Gel, 1% Versus Doxycycline Hyclate 100 mg Administered Once Daily With Metronidazole Topical Gel, 1% in Patients With Moderate to Severe Rosacea

To compare the safety and efficacy of two treatment regimens: 1) COL-101 and metronidazole gel 1%; 2) Doxycycline hyclate 100 mg and metronidazole gel 1%

Compare the safety and efficacy of two treatment regimens: 1) COL-101 and metronidazole gel 1%; 2) Doxycycline hyclate 100 mg and metronidazole gel 1%

Inclusion Criteria:

• 8-40 total lesions
• erythema
• telangiectasia

Exclusion Criteria:

• non-pregnant, non-lactating
• achlorhydric
• gastric by-pass surgery
• allergy to study medications
• drug/alcohol abuse
• use of proton pump inhibitors