PURPOSE: We determined whether Synergo therapy- intravesical chemotherapy instillation combined with hyperthermia instillation is associated with elevated prostate specific antigen (PSA). MATERIALS AND METHODS: We will treat 25 consecutive patients with bladder cancer with a 6-week course of Synergo therapy, followed by cystoscopy at 6 weeks. Blood samples for PSA determination will obtain before each synergo therapy application and at cystoscopy with each patient also serving as a control.

Evaluating changes in PSA level in patients undergoing treatment with Synergo delivered local hyperthermia combined with intravesical instillation of Mitomycin C for adjuvant treatment or pt. with recurrent tu of bladder post TURT with BCGtreatment.

Inclusion Criteria:

• Recurrent transitional cell carcinoma of urinary bladder post endoscopic resection
• PSA Prior synergo therapy application<10
• Normal rectal examination
• Patients willing to sign informed consent according

Exclusion Criteria:

• History of prostate cancer
• Previous history of TCC stage T2 or higher
• Invasive tu of bladder
• Prior pelvic radiotherapy or systemic chemotherapy
• Active prostatitis
• Active tuberculosis