Safety and Efficacy of Intranasal Ketamine for the Treatment of Postoperative Dental Pain

A Randomized, Double-Blind, Placebo-Controlled Pilot Study of the Safety and Efficacy of 10 mg, 30 mg, and 50 mg of Transnasal Ketamine Hydrochloride (PMI-100) for the Treatment of Postoperative Dental Pain

Once patients' postoperative pain intensity reaches a moderate-to-severe level, they are randomized to receive intranasal ketamine or placebo. Patients remain in the study unit for 3 hours post administration and assess pain intensity and pain relief throughout the 3 hour postoperative period.

Inclusion Criteria:

• Healthy patients at least 16 years of age requiring two or more third molar extractions

Exclusion Criteria:

• Less than 16 years old
• Other exclusion criteria may apply