GSK372475 Bioequivalence Study

An Open Label, Randomized, Parallel Groups, Bioequivalence Study to Compare a Single Oral Dose of GSK372475B or GSK372475C in Male and Female Healthy Volunteers.

The study is to show the new salt formulation of GSK372475 is equivalent to the old salt formulation of GSK372475.

Inclusion Criteria:

• Healthy Males/Females aged 18-45 years
• Non-smokers
• BMI 19-30 kg.m2
• QTc<450msec

Exclusion Criteria:

• Use of oral contraception
• Positive breath alcohol and drug screen
• Regular alcohol consumption
• Current psychiatric illness or within 1 year.
• History of GI, hepatic or renal disease
• Uncontrolled hypertension