Effect of Different Doses of Budesonide on Markers of Bone Metabolism in Children With Asthma

Effect of Different Doses of Budesonide on Markers of Bone Metabolism in Children With Asthma - Randomized, Controlled Trial.

The purpose of the trial is to check if inhaled glucocorticosteroids (iGCS) have influence on bone condition (if iGCS increases risk of osteoporosis and bone fraction) in children with asthma.

Asthma is the most prevalent chronic disease of respiratory tract, the largest frequency is noticed in children. iGCS are the basic group of drugs in asthma, because of inflammatory character of disease. All iGCS are absorbed to the systemic circulation (small amounts) despite of local exposition in lungs and possess systemic effects. The purpose of trial is to check if iGCS have influence on bone condition (if iGCS increases risk of osteoporosis and bone fraction) in children with asthma.

Inclusion Criteria:

• Allergic only to house dust mites
• Never treated chronically (longer than at least 3 months) with anti-asthmatic drugs
• Newly-diagnosed or non-treated asthma
• Must be able to inhale drugs

Exclusion Criteria:

• Other allergic diseases requiring treatment with glucocorticosteroids
• Other chronic diseases
• Asthma exacerbation
• Pregnancy