Combination Therapy in Patients With Depression

Noradrenergic Augmentation of SSRI Therapy in Patients With Depression Unresponsive or Incompletely Responsive to SSRI Monotherapy

The purpose of the study is to compare sertraline and atomoxetine/sertraline combination therapy in patients with persistent depressive symptoms.

Inclusion Criteria:

• Meet DSM-IV criteria for major depression with a HAMD-17 rating scale score of at least 18 at visit 1
• Adult men or women, 18 years of age or older
• Must be able to swallow capsules
• Laboratory results must show no clinically significant abnormalities
• If suicidal ideation is present, the investigator should assess its severity and the potential need for other interventions and determine whether these are compatible with study participation

Exclusion Criteria:

• Have a documented history of Bipolar I or II disorder, or of psychosis.
• Have a history of any seizure disorder (other than febrile seizures) or patients who have taken (or are currently taking) anticonvulsants for seizure control.
• Have a history of ADHD
• Have a history of severe allergies to more than 1 class of medications or multiple adverse drug reactions
• Are currently using alcohol, drugs of abuse, or any prescribed or over-the-counter medication in a manner which the investigator considers indicative of abuse