Two stage study looking at different titration schedules in patients with moderate to severe non-malignant chronic pain. Up to 80 patients at approximately 15 centers in the US to be enrolled. Study participation is approximately 3 months.

Inclusion Criteria:

• Opioid experienced
• Hx (min 3 months) of moderate to severe pain of non-malignant that is well controlled with current pain therapy
• On a stable dose of opioid medication for greater than or equal to 14 days
• Have an adequate personal support system including a co-habitant
• Are able and willing to follow verbal and written instructions and provide written informed consent

Exclusion Criteria:

• Are pregnant or lactating
• Have pain secondary to a confirmed or suspected neoplasm
• Have a history or physical examination finding incompatible with safe participation in the study
• Have a history of alcohol or drug abuse
• Have a history or physical examination finding of clinically significant skin abnormalities that would preclude use of a transdermal patch (e.g., psoriasis)
• Have a history of or currently manifesting a clinically significant psychiatric disorder
• Have a known history of allergy that negatively impacts respiratory function to a clinically significant level
• Plan to have an MRI while on the study
• Have any clinically significant condition that would, in the opinion of the investigator, preclude safe study participation
• Are scheduled for surgery requiring general anesthesia within the study period