Systematic Pelvic Lymphadenectomy Versus no Lymphadenectomy in Clinical Stage I-II Endometrial Cancer

The purpose of this trial is to determine whether the addition of systematic pelvic lymphadenectomy to hysterectomy with bilateral adnexectomy improves disease-free survival (DFS) and overall survival (OS) in patients with preoperatively supposed Stage I-II endometrial cancer

Inclusion Criteria:

• Histologically proven endometrioid or adenosquamous endometrial carcinoma.
• Patients having myometrial invasion
• Age =/< 75 years
• Informed consent.

Exclusion Criteria:

• Serous papillary and clear cell tumors.
• Karnofsky index < 80 or severe diseases contraindicating surgery
• Concomitant neoplasia (basalioma cutis excluded)
• Distant metastasis or abdominal metastasis detected intraoperatively.
• Absence of myometrial invasion at frozen section.