Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| The S. Daniel Abraham International Center for Health and Nutrition | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Our specific aim is to determine the impact of folic acid and omega-3 supplementation on the severity of depressive symptoms among depressed adults aged 65 and above.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| omega-3, folic acid, vitB12 | Experimental | folic acid (1600 mcg per day), and omega-3 (2000 mg per day: active docosahexaenoic acid (DHA) and eicosapentanoic acid (EPA), proportion 1:1), vitamin B12 (1000 mcg per day) |
|
| omega-3, folic acid placebo, vit B12 | Experimental | omega-3,folic acid placebo (starch), vitamin B12 (1000 mcg per day) |
|
| omega-3 placebo, folic acid, vit B12 | Experimental | folic acid, omega-3 placebo(canola oil),vitamin B12 (1000 mcg per day) |
|
| omega-3 placebo, folic acid placebo, vit B12 | Experimental | omega-3 placebo (canola oil),folic acid placebo (starch), vitamin B12 (1000 mcg per day) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| folic acid | Dietary Supplement |
| ||
| omega-3 |
| Measure | Description | Time Frame |
|---|---|---|
| the severity of depressive symptoms | baseline, 4th , 8th and 12th week |
| Measure | Description | Time Frame |
|---|---|---|
| cognitive status | baseline, 4th, 8th, and 12th week | |
| nutritional status | baseline and end of study | |
| possible side effects |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Danit R Shahar, RD PhD | Ben-Gurion University of the Negev | Study Director |
| Alex Palatnik, MD | Beersheva Mental Health Center | Principal Investigator |
| Larissa German, MD, MMedSc | The S. Daniel Abraham International Center for Health and Nutrition | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mental Health Center | Beersheba | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34817851 | Derived | Appleton KM, Voyias PD, Sallis HM, Dawson S, Ness AR, Churchill R, Perry R. Omega-3 fatty acids for depression in adults. Cochrane Database Syst Rev. 2021 Nov 24;11(11):CD004692. doi: 10.1002/14651858.CD004692.pub5. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
Not provided
Not provided
| ID | Term |
|---|---|
| D005492 | Folic Acid |
| D004281 | Docosahexaenoic Acids |
| D014805 | Vitamin B 12 |
| ID | Term |
|---|---|
| D011622 | Pterins |
| D011621 | Pteridines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Dietary Supplement |
|
| vit B12 | Dietary Supplement |
|
| folic acid placebo | Other |
|
| omega-3 placebo | Other |
|
| baseline, 4th, 8th, and 12th week |
| D006571 | Heterocyclic Compounds |
| D015525 | Fatty Acids, Omega-3 |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |
| D045728 | Corrinoids |
| D045725 | Tetrapyrroles |
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |