Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Current influenza vaccines have a reduced efficacy in the elderly. This study will investigate the immunogenicity, safety and tolerability of an adjuvanted influenza vaccine in elderly participants.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Inactivated trivalent influenza vaccine |
|
| 2 | Experimental | CSL412 formulation |
|
| 3 | Experimental | CSL412 formulation |
|
| 4 | Experimental | CSL412 formulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CSL412 | Biological |
| ||
| Inactivated trivalent influenza vaccine |
| Measure | Description | Time Frame |
|---|---|---|
| seroprotection rate, HI titre & seroconversion/ significant increase | ||
| grade 3 or higher, vaccine associated fever or vaccine associated site ulceration, abscess or necrosis |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Elizabeth Hancox, Dr | Chiltern International | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chiltern International | Slough | United Kingdom |
Not provided
| ID | Term |
|---|---|
| D007251 | Influenza, Human |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Biological |
|
| D014777 | Virus Diseases |
| D012140 | Respiratory Tract Diseases |