The purpose of this study is to investigate the effect of up to 200 mg of PF-00446687 on acute sexual arousal and sexual interest in post menopausal females, as well as examining the safety and toleration of the drug.

Inclusion Criteria:

• Women who have evidence of Female Sexual Arousal Disorder.
• Women who experience personal distress due to Female Sexual Dysfunction.
• Post menopausal women aged between 45 and 65 years.

Exclusion Criteria:

• Women whose sexual dysfunction is limited to certain types of stimulation, situation or specific partners.
• Women who experience pain with sexual intercourse or who have a sexual aversion disorder.
• Women suffering from female sexual dysfunction where the cause is treatable, for example inadequately controlled diabetes or thyroid dysfunction.