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Previous studies have shown that alcohol significantly impairs driving performance. Acute alcohol administration also has a detrimental effect on secondary task performance during dual-tasks. The present study will investigate the effects of five different dosages of ethanol (0,0.2, 0,5, 0,8 and 1,0 % BAC) on performance in a driving simulator. Steering performance and brain activity will be recorded in both single- and dual-task conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Experimental | alcohol and placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| alcohol | Drug | alcohol(0.02%, 0.05%, 0.08% and 0.10%) and placebo |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Primary parameter of the steering simulator is the standard deviation of the car from the center of the road (steering error). | 5 testdays |
| Measure | Description | Time Frame |
|---|---|---|
| Reaction speed after hearing the deviant target tone. Brain activity: ERPs of interest are the mismatch negativity (MMN), P3a, P3b, and reorienting negativity (RON) | 5 testdays |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joris C Verster, PhD | Utrecht Institute for Pharmaceutical Sciences | Principal Investigator |
| Edmund R Volkerts, PhD | Utrecht Institute for Pharmaceutical Sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Utrecht Institute for Pharmaceutical Sciences | Utrecht | Utrecht | Netherlands |
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| ID | Term |
|---|---|
| D000437 | Alcoholism |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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