Effect of Memantine on Functional Communication in Patients With Alzheimer's Disease

A Randomized, Double-Blind, Placebo-Controlled Evaluation of the Efficacy of Memantine on Functional Communication in Patients With Alzheimer's Disease (AD)

The objective of this study is to evaluate the effect of memantine versus placebo on functional communication in patients with Alzheimer's Disease

Inclusion Criteria:

• Male and female outpatients, 50 years or older, native English speakers, meeting National Institute of Neurological and Communicative Disorders and Stroke--Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable AD with a Mini Mental State Examination (MMSE) score of 10 to 19 at Screening and Baseline

Exclusion Criteria:

• Current Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition (DSM-IV) Axis I disorder other than AD
• Previous imaging results not consistent with the diagnosis of AD
• Modified Hachinski Ischemia Score greater than 4
• Evidence of other neurologic disorders
• Clinically significant systemic disease
• A known or suspected history of alcohol or drug abuse in the past 5 years
• Taking excluded medication
• Previous treatment with commercial memantine