Evaluation of NT PRO BNP Guided Therapy on Hospitalization Rate and Mortality in Patients With Chronic HF NYHA II-IY

Phase 1 Study of Using BNP as Guided Parameter in Treatment HF

To use continuous measurement of NT Pro BNP level as guide in therapy patients with CHF.

Group of 100 patients with CHF, NYHA II-IY will be followed for 1 years in outpatient clinic of our hospital for hospitalization, death, 6 min walking protocol, number of decompensation as a primary end point. 50 patients will be treated according usual practice in outpatient clinics and in 50 patients will be additionally used level of NT Pro BNP as additional parameter.If level NT Pro BNP will be goes down will not be changes in treatment regiment. If level of NT Pro BNP will be increased treatment will be intensified.At the end of 1 year follow up we will compare the result of two strategies.

Inclusion Criteria:

• Patient older 18 y.old with CHF NYHA II-IY.

Exclusion Criteria:

• All conditions with life expectancy less than 2 years.