A Study Comparing Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections With Insulin Lispro and Glargine

A Study Comparing Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections With Insulin Lispro and Glargine

This trial will compare the metabolic control in type 1 diabetes obtained by continuous infusion of insulin lispro with that obtained by multiple daily injections of insulin lispro and glargine, a long-acting insulin analogue. Patients will be switched to the alternative treatment after 4 months. Glucose variability in the last month of each treatment will be analyzed.

Inclusion Criteria:

• Type 1 diabetic patients, 18-60 years of age
• Diabetic for >2 years
• Treated with CSII for >=6 months
• HbA1c <8.5%

Exclusion Criteria:

• Treatment with daily insulin injections
• Inability to handle pump therapy
• Untreated retinopathy