Absorption, Distribution, Metabolism And Excretion Study For GSK221149A

An Open-label, Two Period Study to Determine the Excretion Balance and Pharmacokinetics of [14C]-GSK221149A, Administered as Single Doses of an Oral Solution and an Intravenous Infusion to Healthy Female Volunteers

This is a phase one study investigating the absorption, distribution, metabolism and excretion of GSK221149A in six healthy women of non-child bearing potential.

Inclusion criteria:

• Healthy adult, non-smoking females
• Aged between 30 - 55 years old, and BMI of between 19 and 32
• Not of child-bearing potential

Exclusion criteria:

• No clinically significant findings on clinical examination, medical examination and blood tests.
• Radiation exposure over previous 3 years is greater than 10mSv
• History of bleeding or gastric problems