A Safety and Efficacy Study With YM543 in Type 2 Diabetes Mellitus Subjects

A Randomized, Double Blind, Placebo and Active Controlled, Dose Escalation Study to Evaluate the Safety, Tolerability and Potential Efficacy of a 12-Week Treatment With YM543 in Subjects With Type 2 Diabetes Mellitus

The purpose of this study is to investigate the safety of YM543 in type 2 Diabetes Mellitus patients and to investigate whether this study drug is effective in these patients

Inclusion Criteria:

• Treatment-naive subjects diagnosed with T2DM
• Stable diet and exercise program for at least 6 weeks
• Inadequate glycemic control indicated by HbA1c and FPG level at Visit 1

Exclusion Criteria:

• Any known complication of T2DM indicating a late disease state, clinical manifestations of macro- and/or micro vascular disorders
• Use of insulin or oral blood glucose lowering drugs in the last 3 months