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The primary purpose of this protocol is to investigate the safety and tolerability of AZD8330 (ARRY-424704) in patients with Advanced Malignancies
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AZD8330 | Drug | oral tablet |
|
| Measure | Description | Time Frame |
|---|---|---|
| To assess safety and tolerability of AZD8330 in patient with advanced malignancies. | ||
| Outcome variables: Adverse Events, Clinical Chemistry, Haematology, Urinalysis, Vital signs, MUGA scans/echocardiography, ECGs, Ophthalmologic examination, O2 saturation |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the PK of AZD8330. | ||
| To investigate possible PD/PK relationships | ||
| To investigate effect of AZD8330 on pERK in PBMCs |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Emerging Oncology Medical Science Director, MD | AstraZeneca | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Philadelphia | Pennsylvania | United States | |||
| Research Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23433846 | Derived | Cohen RB, Aamdal S, Nyakas M, Cavallin M, Green D, Learoyd M, Smith I, Kurzrock R. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49(7):1521-9. doi: 10.1016/j.ejca.2013.01.013. Epub 2013 Feb 21. |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| C581956 | AZD8330 |
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| Houston |
| Texas |
| United States |
| Research Site | Oslo | Norway |