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There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve. Pulmonary hypertension (PH)is a disease characterized by low oxygen levels in the blood and altered blood circulation. The decrease in oxygen delivery to the optic nerve could lead to the loss of nerve fiber layer(NFL)in the retina and the resulting visual field compromise. This situation is characteristic of glaucoma. The ability to identify NFL thinning early could lead to earlier diagnosis of glaucoma and more effective treatment to limit dysfunction from visual field loss.
We hypothesize that the rate of structural damage to the NFL, a feature of glaucoma, is higher in patients with PH than expected in healthy populations lacking this disease.
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| Measure | Description | Time Frame |
|---|---|---|
| Occurence of nerve fiber layer abnormalities | Single Exam |
| Measure | Description | Time Frame |
|---|---|---|
| Optic Nerve Head Structure | Single Exam |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Field Defects | Single Exam | |
| Retinal Blood Flow Changes | Single Exam |
Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with pulmonary hypertension
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| Name | Affiliation | Role |
|---|---|---|
| Malik Y. Kahook, M.D. | University of Colorado School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Eye Center | Aurora | Colorado | 80045 | United States |
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| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D006976 | Hypertension, Pulmonary |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| D006973 |
| Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |