Molecular Epidemiology Case-Series Study of Non-Small Cell Lung Cancer in Smoking and Non-Smoking Women and Men
Molecular Epidemiology Case-Series Study of Non-Small Cell Lung Cancer in Smoking and Non-Smoking Women and Men
RATIONALE: Studying samples of blood and tissue from smokers (closed to entry as of 7/15/07) and non-smokers with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about risk factors for lung cancer and may help the study of cancer in the future.
PURPOSE: This clinical trial is studying carcinogens in lung tissue from smokers (closed to entry as of 7/15/07) and non-smokers with newly diagnosed stage I, stage II, or stage III non-small cell lung cancer.
OBJECTIVES:
OUTLINE: This is a case-series, multicenter study. Patients are stratified according to gender and smoking status (never smoker [< 100 cigarettes smoked during lifetime] vs ever smoker [≥ 100 cigarettes smoked during lifetime] [closed to accrual as of 7/15/07]).
Patients complete the Lung Cancer Epidemiology Questionnaire for detailed assessment of the following:
Patients are followed annually for up to 5 years.
PROJECTED ACCRUAL: A total of 900 patients will be accrued for this study (female and male smoker strata closed to accrual as of 7/15/07).
DISEASE CHARACTERISTICS:
Histologically confirmed non-small cell lung cancer
Stage I, II, IIIA, or IIIB (T4 or N3) disease
No malignant pleural effusion; if pleural fluid is present, 1 of the following criteria must be met:
No diagnosis by cytology alone
Newly diagnosed disease
Must have tumor blocks/slides available and must be willing to provide tissue samples
Prior smoking history meeting 1 of the following criteria:
No pericardial effusions
PATIENT CHARACTERISTICS:
No other prior malignancy except for 1 of the following:
PRIOR CONCURRENT THERAPY:
Tucson, Arizona 85724-5024, United States
Fort Smith, Arkansas 72903, United States
Burbank, California 91505, United States
Concord, California 94524-4110, United States
Marysville, California 95901, United States
Orange, California 92868, United States
Pomona, California 91767, United States
San Francisco, California 94115, United States
Santa Clara, California 95051, United States
South San Francisco, California 94080, United States
Hartford, Connecticut 06105, United States
Fort Lauderdale, Florida 33308, United States
Savannah, Georgia 31403-3089, United States
Savannah, Georgia 31405, United States
Chicago, Illinois 60657, United States
Maywood, Illinois 60153, United States
Beech Grove, Indiana 46107, United States
Kansas City, Kansas 66160-7357, United States
Wichita, Kansas 67214, United States
Ashland, Kentucky 41101-0151, United States
Shreveport, Louisiana 71130-3932, United States
Dearborn, Michigan 48123-2500, United States
Grosse Pointe Woods, Michigan 48236, United States
Southfield, Michigan 48075, United States
Minneapolis, Minnesota 55407, United States
Robbinsdale, Minnesota 55422-2900, United States
St Louis, Missouri 63141, United States
Billings, Montana 59102, United States
Missoula, Montana 59807, United States
Concord, New Hampshire 03301, United States
Manhasset, New York 11030, United States
New York, New York 10032, United States
Rochester, New York 14621, United States
Rochester, New York 14642, United States
Charlotte, North Carolina 28233-3549, United States
Wright-Patterson AFB, Ohio 45433-5529, United States
Portland, Oregon 97213-2967, United States
Portland, Oregon 97239-3098, United States
Allentown, Pennsylvania 18105, United States
Pittsburgh, Pennsylvania 15224-1791, United States
Greenwood, South Carolina 29646, United States
Greer, South Carolina 29650, United States
Spartanburg, South Carolina 29303, United States
Sioux Falls, South Dakota 57117-5039, United States
Murray, Utah 84157, United States
Burlington, Vermont 05401, United States
Seattle, Washington 98122-4307, United States
Seattle, Washington 98195, United States
Eau Claire, Wisconsin 54701, United States
Green Bay, Wisconsin 54301-3526, United States
Manitowoc, Wisconsin 54221-1450, United States
Milwaukee, Wisconsin 53215, United States