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The purpose of this study is to determine the maximum tolerated dose of ZD6474 given in combination with radiation or in combination with chemotherapy and radiation in patients with squamous cell carcinoma of the head and neck.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Radiation + vandetanib |
|
| 2 | Experimental | Radiation + cisplatin + vandetanib |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ZD6474 (vandetanib) | Drug | once daily oral dose |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| To determine the maximum tolerated dose of vandetanib given in combination with radiation or radiation and chemotherapy in patients with late stage head and neck cancer | assessed at each visit |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Sciences & Operations | Sanofi | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Denver | Colorado | United States | |||
| Research Site |
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| Label | URL |
|---|---|
| CSR-D4200C00062.pdf | View source |
| protocol redacted | View source |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D002294 | Carcinoma, Squamous Cell |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
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| ID | Term |
|---|---|
| C452423 | vandetanib |
| D002945 | Cisplatin |
| D011827 | Radiation |
| ID | Term |
|---|---|
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
| D017671 | Platinum Compounds |
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| Cisplatin | Drug | intravenous infusion |
|
| Radiation | Radiation | radiation of head and neck |
|
| Chicago |
| Illinois |
| United States |
| Research Site | Dallas | Texas | United States |
| Research Site | Houston | Texas | United States |
| D009370 |
| Neoplasms by Histologic Type |
| D018307 | Neoplasms, Squamous Cell |
| D055585 |
| Physical Phenomena |