Gel-200 Extension and Open-Label Study in Osteoarthritis of the Knee

A Multi-Center Extension and Open-Label Study of a Single or Repeat Intra-Articular Injection of Gel-200 in Osteoarthritis of the Knee.

The purpose of this study is to determine if a single or repeat intra-articular injection of Gel-200 is safe and effective in subjects with symptomatic osteoarthritis of the knee and to determine if original SI-6606/01 Gel-200 therapy is durable beyond the original study.

Inclusion Criteria:

• Previous participation in study SI-6606/01.

Exclusion Criteria:

• Female subjects who are pregnant or lactating.