Effect of Conjugated Linoleic Acid Intake on Liver and Kidney Function

The Effect of Conjugated Linoleic Acid Intake on Liver and Kidney Function in Healthy Volunteers (CLAxon-Study)

The knowledge of the health effects of CLA on the human body is limited. However, CLA supplements are sold over the counter in several countries and various techniques are used to increase the content of CLA in food.

The CLAxon-study will be performed to investigate wether high doses of CLA can be safely given to healthy human volunteers.

Each volunteer receives CLA enriched products for a total of 3 weeks containing approximately 20g CLA per day. A control group is not needed. If three subjects or more show one or more blood values for liver and kidney function above predefined limits the study will be terminated.

Inclusion Criteria:

• age 18-60 years
• serum total cholesterol < 8.0 mmol/L
• serum triglycerides < 3.0 mmol/L
• ALAT < 45 IU/L
• ASAT < 41 IU/L
• amylase 35-130 U/L
• alkaline phosphatase 40-125 U/L
• bilirubin < 17 µmol/L
• gamma-glutamyltranspeptidase > 75 U/L (men) and < 40 U/L (women)
• lactate dehydrogenase 230-485 U/L
• creatinine clearance >= 90 mL/min
• fasting glucose levels 70-115 mg/dL
• fasting insulin levels 5-30 mU/L

Exclusion Criteria:

• use of cholesterol lowering medication
• high alcohol intake
• BMI > 30
• chronic diseases (such as diabetes, cardiovascular disease, kidney and liver dysfunction)
• pregnancy