Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques

Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques

Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences. Atherosclerotic plaques normally removed during surgery, and peripheral blood samples will be studied to achieve the following objectives:

"1" Define histological features of the vulnerable plaque, analyze its physical characteristics, and investigate selected gene expression.

"2" Study biomarkers of inflammation in conjunction with the presence of vulnerable plaques.

"3" Explore the potential role of infection in atherogenesis.

Inclusion Criteria:

• Evidence of symptomatic carotid stenosis exceeding 60%(TIAs or stroke within the last 6 months), and asymptomatic carotid artery stenosis (presenting with progressive carotid stenosis, exceeding 70%)
• Abdominal aortic aneurysm, and aortic occlusive disease
• Peripheral occlusive or aneurysmal disease

Exclusion Criteria:

• Non-compliant patients, incapable of granting approval by informed consent