Treatment of Advanced Hodgkin's Disease (Stages IIB-III-IV)

Treatment of Advanced Hodgkin's Disease (Stages IIB-III-IV)

The purpose of this study is to compare the toxicities of the COPPEBVCAD vs BEACOPP vs ABVD regimens.

Inclusion Criteria:

• Histologically confirmed diagnosis of Hodgkin disease
• Clinical stage IIB, III, IV
• No prior treatment for Hodgkin disease or other malignancy
• Age 18-65 year
• Good cardiac, pulmunar, renal and hepatic function
• Performance status 0-3 (Karnofsky 100- 40)
• Written Informed Consent

Exclusion Criteria:

• HIV positivity
• Large cell, anaplastic, CD30+ lymphoma