Treatment of Severe Limb Ischemia With Autologous Bonemarrow Derived Mononuclear Cells

Treatment of Severe Limb Ischemia With Autologous Bonemarrow Derived Mononuclear Cells

The aim of the study is to investigate whether implantation of autologous bone marrow derived stem cells in ishemics limbs will improve vascularization

10 patients with severe lower limb ischemia will be included in this pilote trial.

Bonemarrow aspiration will be performed and and the monocuclear cells isolated an injected into the gastrocnemius.

The patiens are followed for 4 months. Were trancutaneous oxygenpressure, ankel and toe blood pressure is measured.

Inclusion Criteria:

• Ankle blood pressure < 70 mmgHG
• Either pain at rest and/or ischemic wound
• No possible surgical treatment

Exclusion Criteria:

• Infection
• Malignant disease