Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence (ALC-DRD2-APO)

Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence: Predictive Value for Relapse

OH dependence is associated with DA receptor changes. Both, the apomorphine test and the D2Rec SPECt are usefull for monitoring DA receptor status. We aimed at studying whether DA receptor hypofunction, assessed by means of the apomorphine test and the D2Rec SPECT, is a marker of relapse in detoxified OH dependents patients.

Inclusion Criteria:

• alcohol dependence
• alcohol dependence length at least 8 years.
• male
• age 25 - 60 years

Exclusion Criteria:

• other drug dependence (except nicotine dependence)
• another major axis I psychiatric diagnosis
• comorbid neurological disorder
• comorbid cardiovascular disorder
• comorbid metabolic disorder
• brain injury
• apomorphine allergy
• iode allergy
• diazepam allergy