Dalteparin Versus Unfractionated Heparin In Patients With Acute Coronary Syndrome

Prospective Randomized Phase IV Open Label Comparative Study Of Dalteparin vs Unfractionated Heparin In High Risk Patients Of Non-ST Elevation Acute Coronary Syndromes Intended For Early Invasive Strategy

To compare efficacy and safety of dalteparin compared to unfractionated heparin in patients of non ST elevation acute coronary syndromes who are planned to undergo coronary interventions (angioplasty or bypass surgery)

The study was prematurely discontinued on November 30, 2008 due to delay in meeting pre-defined protocol recruitment milestones. There were no safety concerns regarding the study in the decision to terminate the trial.

Inclusion Criteria:

• Patients more than 18 years
• Ischemic pain of more than 10 minutes within 24 hours before enrollment
• At least two of the following three risk factors : Age more than 60 years ( or more than 50 in case of diabetics), Raised cardiac enzyme levels, abnormal ECG findings

Exclusion Criteria:

• Contraindications to use of anticoagulants
• Active bleeding or abnormal coagulation tests
• Ischemic stroke within last 6 months or hemorrhagic stroke
• Lumbar or spinal puncture within last 48 hours
• S creatinine levels more than 2