Comparative Study of the Effect of Dysport and Botox

A Comparative Randomized Double-Blinded Study of the Effect of Dysport and Botox on Forehead Wrinkles and EMG Activity

The purpose of this study is to test the effect of Dysport and Botox on forehead wrinkles and EMG activity.

Inclusion Criteria:

• age between 30 and 70 years
• moderate to severe hyperfunctional forehead wrinkles at maximum contraction and at rest

Exclusion Criteria:

• application of botulinum toxin products for a period of 12 months prior to the study
• any significant health disturbances
• facial nerve palsy, and any facial conditions that could confound safety or efficacy results
• pregnancy and breast-feeding
• neuromuscular diseases
• drugs interfering with neuromuscular function (e.g. aminoglycosides)