Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The investigators want to investigate the effects of two different kinds of fluid infusions given during varicose vein surgery. Both types of fluid are regularly given during surgery, and the investigators want to compare their respective effects on balance, nausea/vomiting and orthostatic function after surgery.
The investigators' hypothesis is that using a colloid solution will improve orthostatic function, balance, nausea/vomiting and reduce hospital stay.
The optimal amount and type of fluid given during surgery has not been defined. It has been agreed that hypovolemia must be avoided, but at the same time it has been agreed that fluid excess is harmful for organ function.When distributing fluids it is usually either crystalloids og colloids which are given. The effects of the two types of fluid have not been compared. Our hypothesis is that using a colloid (HES 130/0,4) will improve orthostatic function, nausea/vomiting and shorten hospital stay, compared to using a crystalloid (Lactated Ringer's solution).The amount of fluid the patient receives, will be individually tailored by monitoring SV using esophageal Doppler technique during surgery.
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hydroxyethylstarch 130/0,4 | Drug | |||
| Lactated Ringer's solution | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| To investigate orthostatic function, measured by Finapress |
| Measure | Description | Time Frame |
|---|---|---|
| To investigate the occurrence of postsurgery nausea/vomiting. | ||
| To investigate the amount of time until discharge criteria from the Postanaesthetic Care Unit have been achieved. | ||
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Morten Bundgaard-Nielsen, M.D. | Contact | 0045 35452674 | morten.bundgaard-nielsen@rh.hosp.dk | |
| Henrik Kehlet, M.D. Ph.d | Contact | 0045 35454074 | henrik.kehlet@rh.hosp.dk |
| Name | Affiliation | Role |
|---|---|---|
| Henrik Kehlet, M.D. Ph.d. | dept of surgical patophysiology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept of anesthesia 2041, ABD centre, Rigshospitalet, Blegdamsvej | Copenhagen | Region Sjælland | 2200 | Denmark |
Not provided
| ID | Term |
|---|---|
| D000077325 | Ringer's Lactate |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| To investigate balance function, measured by BalanceMaster |