Fluid Infusion During Breast Surgery

Phase 4 Study of Fluid Infusion During Breast Surgery.

The investigators want to investigate the effects of two different kinds of fluid infusions given during varicose vein surgery. Both types of fluid are regularly given during surgery, and the investigators want to compare their respective effects on balance, nausea/vomiting and orthostatic function after surgery.

The investigators' hypothesis is that using a colloid solution will improve orthostatic function, balance, nausea/vomiting and reduce hospital stay.

The optimal amount and type of fluid given during surgery has not been defined. It has been agreed that hypovolemia must be avoided, but at the same time it has been agreed that fluid excess is harmful for organ function.When distributing fluids it is usually either crystalloids og colloids which are given. The effects of the two types of fluid have not been compared. Our hypothesis is that using a colloid (HES 130/0,4) will improve orthostatic function, nausea/vomiting and shorten hospital stay, compared to using a crystalloid (Lactated Ringer's solution).The amount of fluid the patient receives, will be individually tailored by monitoring SV using esophageal Doppler technique during surgery.

Inclusion Criteria:

• Patients having performed elective breast surgery.
• Age between 18 and 70 years
• Patients who have given written consent to participate in the project after haven completely understood the contents and limitations of the protocol.

Exclusion Criteria:

• Patients who do not understand or speak Danish
• Patients who have not signed the informed consent or the written authority
• pre-medication, except 1g paracetamol
• ASA > II
• Pregnant or breastfeeding
• Known to have Renal disease
• Known to have Psychiatric disorder (not considering the use of SSRI antidepressive)
• Need for crash induction or prone position.
• Oesophageal varicoses
• Necrosis or cancer in: Mouth, Pharynx, Larynx or Oesophagus
• Coarctation or aneurism in the proximal Aorta
• Severe bleeding disease