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| Name | Class |
|---|---|
| ReVision Therapeutics, Inc. | OTHER |
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The purpose of this phase II study is to determine the efficacy of fenretinide in the treatment of geographic atrophy (GA) in subjects with the dry form of age-related macular degeneration (AMD).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 100 mg fenretinide softgel capsules | Active Comparator | Three (3) 100-mg fenretinide softgel capsules |
|
| Fenretinide and placebo softgel capsules | Active Comparator | One (1) 100-mg fenretinide softgel capsule and two (2) placebo softgel capsules |
|
| Placebo softgel capsules | Placebo Comparator | Three (3) placebo softgel capsules |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fenretinide | Drug | Once daily 30 minutes after the evening meal for 24 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| GA lesion progression | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Roger Vogel, MD | ReVision Therapeutics Advisor | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33331670 | Derived | Yeong JL, Loveman E, Colquitt JL, Royle P, Waugh N, Lois N. Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to age-related macular degeneration. Cochrane Database Syst Rev. 2020 Dec 17;12(12):CD013154. doi: 10.1002/14651858.CD013154.pub2. |
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| ID | Term |
|---|---|
| D057092 | Geographic Atrophy |
| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D017313 | Fenretinide |
| ID | Term |
|---|---|
| D012176 | Retinoids |
| D002338 | Carotenoids |
| D011090 | Polyenes |
| D000475 | Alkenes |
| D006839 |
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| Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D053138 | Cyclohexenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D013729 | Terpenes |
| D010860 | Pigments, Biological |
| D001685 | Biological Factors |