Treatment Protocol for Hemophagocytic Lymphohistiocytosis 2004

HLH-2004 Treatment Protocol

Without therapy HLH is often fatal, and often rapidly fatal. The treatment protocol HLH-94 has improved survival markedly as compared to the survival earlier. We now aim to improve survival further.

The most dangerous period after HLH diagnosis is the first 2 months. In HLH-2004 we provide additional therapy during this period as compared to in HLH-94.

Inclusion Criteria:

• Patients who fulfil the diagnostic criteria of HLH.

Exclusion Criteria:

• Prior cytotoxic or cyclosporin treatment for HLH.