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| ID | Type | Description | Link |
|---|---|---|---|
| ID RCB 2006-A00196-45 | |||
| DGS2006-0090 |
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Experimental results are strongly suggesting that PCSK9 and FXR could occur in the physiopathology of human joined dyslipidemia. But no data in the literature can validate the potential role of these two genes in the lipidic and glucidic metabolism control in physiopathological situations. This protocol is based on the hypothesis that the expression levels of PCSK 9 and FXR are modified for some patients suffering from insulin resistance and dyslipidemia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Non diabetic non dyslipidemic patient |
|
| 2 | Experimental | Patient with metabolic syndrome |
|
| 3 | Experimental | Patients with type II diabetes |
|
| 4 | Experimental | Patient with a single lipidic anomaly |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biopsy of muscle, of liver, and of adipose tissue | Procedure | biopsy of muscle, of liver, and of adipose tissue |
|
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the relationship between the expression levels of PCSK9 and FXR in the liver, adipose tissue and muscle and the different components of the insulin resistance syndrome obese patients submitted to bariatric surgery | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Relationship between the levels of hepatic expression of PCSK9 and FXR and the degree of NASH in these patients. - Search for mutations and polymorphisms in the gene PCSK9 and FXR and their promoter regions | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bertrand Cariou, MD | Nantes University Hospital | Principal Investigator |
| Michel Krempf, MD | Nantes University Hospital | Principal Investigator |
| Yassine Zaïr, MD | Nantes University Hospital | Principal Investigator |
| Eric Letessier, MD | Nantes University Hospital | Principal Investigator |
| Charles Couet, MD | CHU de Tours | Principal Investigator |
| Noël Huten, MD | CHU de Tours | Principal Investigator |
| Philippe Topart, MD | CHU de Brest | Principal Investigator |
| David Lechaux, MD | CHU de St Brieuc | Principal Investigator |
| Jean-Pierre Faure, MD | Poitiers University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nantes | Nantes | 44093 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32032671 | Derived | Blanchard C, Ledoux S, Verhaegen A, Wargny M, Letessier E, Stepanian A, Huten N, Jacobi D, Krempf M, Le Bras M, Perrocheau Guillouche M, Arnaud L, Pichelin M, Van Gaal L, Cariou B, Le May C. Roux-en-Y gastric bypass, but not sleeve gastrectomy, decreases plasma PCSK9 levels in morbidly obese patients. Diabetes Metab. 2020 Nov;46(6):480-487. doi: 10.1016/j.diabet.2020.01.003. Epub 2020 Feb 4. |
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| clamp euglycemic - hyperglycemic | Procedure | clamp euglycemic-hyperglycemic |
|
| diet | Behavioral | diet |
|
| biopsies for biological and genetic analyses | Other | biopsies for biological and genetic analyses |
|
| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D008110 | Liver Extracts |
| D004032 | Diet |
| D001706 | Biopsy |
| D001688 | Biological Products |
| ID | Term |
|---|---|
| D014020 | Tissue Extracts |
| D045424 | Complex Mixtures |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D003949 | Diagnostic Techniques, Surgical |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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