The purpose of this study is to evaluate the potential inhibitory effects of patupilone on metabolism using midazolam and omeprazole as the respective probe drugs.

Inclusion criteria:

• Male or female patients 18 years or older
• Histologically documented advanced solid tumor, who have failed standard systemic therapy, or for whom standard systemic therapy does not exist
• Life expectancy of 3 months or more
• Patients with adequate hematologic parameters

Exclusion criteria:

• Hypersensitivity to midazolam or omeprazole or related compounds
• Female patients who are pregnant or breast-feeding.
• Patients with a severe and/or uncontrolled medical disease
• Patients with a known diagnosis of human immunodeficiency virus (HIV) infection
• Patients having received an investigational agent within 30 days prior to study entry

Other protocol defined inclusion/exclusion criteria may apply.