This study will evaluate the Maximum Tolerated Dose and dose limiting toxicity of gimatecan administered orally in patients with advanced solid tumors

Inclusion criteria:

• Advanced or metastatic cancer
• 18 years and above

Exclusion criteria:

• Previous treatment with 4 or more cycles of carboplatin;
• Previous treatment with 2 or more courses of nitrosourea or mitomycin;
• Previous radiation therapy greater than or equal to 25% of the hematopoietic reserve;
• Severe and/or uncontrolled medical conditions

Other protocol-defined inclusion/exclusion criteria may apply